domingo, 31 de enero de 2021

Androgynous brains

We discovered that brains were indeed distributed across the entire continuum rather than just at the two ends. In a subsample, approximately 25% of brains were identified as male, 25% as female and 50% were distributed across the androgynous section of the continuum. What’s more, we found that participants who mapped at the centre of this continuum, representing androgyny, had fewer mental health symptoms, such as depression and anxiety, compared with those at the two extreme ends.

These findings support our novel hypothesis that there exists a neuroimaging concept of brain androgyny, which may be associated with better mental health in a similar way to psychological androgyny.
Why androgyny benefits us

To learn new things in order to adapt to the ever-changing global environment, we need to be able to be attentive to the world around us. We must also have mental wellbeing, flexibility and be able to employ a wide range of life strategies.

These skills enable us to rapidly understand external context and decide on the optimal response. They help us take advantage of time-limited opportunities and instil resilience. Therefore, these skills confer an advantage for people with androgynous brains, with others being less likely to flourish.
Authors: Barbara Jacquelyn Sahakian, Professor of Clinical Neuropsychology, University of Cambridge;Christelle Langley, Postdoctoral Research Associate, Cognitive Neuroscience, University of Cambridge;Qiang Luo, Associate Principal Investigator of Neuroscience, Fudan University, and Yi Zhang, Visiting Phd Candidate, University of Cambridge

Mappingignorance

jueves, 28 de enero de 2021

ARNm

El ARN mensajero, nuestro Hermes celular A causa de la pandemia de Covid-19, el ARN mensajero (ARNm) se ha convertido en tema de conversación en calles y bares debido a que las dos primeras vacunas aprobadas en Europa para esta enfermedad usaban esta tecnología por primera vez (puedes aprender más sobre el funcionamiento de estas vacunas en este artículo de Lluis Montoliu). Pero lo cierto es que el ARNm forma parte de nuestra historia como seres vivos hace varios miles de millones de años (a este respecto, te aconsejo este artículo de Carlos Briones). Se cree que esta molécula podría estar en el inicio del origen de la vida y forma una parte fundamental de nuestra biología, siendo un componente esencial del conocido como dogma central de la biología molecular. Básicamente, este dogma nos dice que un gen contiene la información necesaria para fabricar una proteína, y para ello primero se transcribe el gen desde la secuencia de doble hebra de ADN una secuencia de una sola hebra de ARNm. Recuerda que el ADN se construye con las «letras» A, T, C y G (donde las letras A/T y G/C son complementarias) mientras que en el ARN estas letras son A, U, C y G (siendo complementarias A/U y G/C). 

lunes, 25 de enero de 2021

Biomonitorización de metales pesados con musgos

¿Por qué crecen más unas especies de colonizadores, como es el caso de los musgos o los líquenes, en un lugar y no en otro? En opinión de la investigadora del grupo IBeA de la UPV/EHU Maite Maguregui, “ya solo visualmente, la presencia de algunas especies nos puede estar dando una idea de si la atmosfera de una determinada zona está más o menos contaminada, dependiendo de la especie de que se trata. El crecimiento de ciertas especies que son más o menos resistentes a la contaminación nos estaría dando información de la calidad atmosférica, por lo menos en el ámbito de los metales del material particulado”.

La biomonitorización es una metodología que considera el uso de organismos vivos para vigilar y evaluar el impacto de diferentes contaminantes en una zona conocida, relativamente barata y fácil de aplicar. Estos organismos, que tienen la capacidad de vigilar la contaminación, se conocen también como biomonitores pasivos, ya que son capaces de identificar posibles fuentes de contaminación sin necesidad de ningún instrumento adicional.

En el estudio realizado con muestras de seis emplazamientos vizcaínos (Muskiz, Getxo, Lutxana, Zamudio, Basauri y Amorebieta-Etxano), se aplicó una metodología multianalítica para verificar la utilidad de los musgos del género Grimmia que crecen naturalmente como biomonitores pasivos de la contaminación atmosférica por metales pesados. Una vez identificados los musgos según su morfología y taxonomía, se determinó la capacidad de los mismos para acumular material particulado, se identificaron las principales partículas metálicas depositadas y, finalmente, se definieron con mayor precisión los niveles de metales acumulados en cada musgo recogido.

Euler Gallego-Cartagena, Héctor Morillas, José Antonio Carrero, Juan Manuel Madariaga, Maite Maguregui (2021) Naturally growing grimmiaceae family mosses as passive biomonitors of heavy metals pollution in urban-industrial atmospheres from the Bilbao Metropolitan area Chemosphere doi: 10.1016/j.chemosphere.2020.128190

Cuaderno de cultura científica

El extraño caso de la curación de un linfoma de Hodgkin



El extraño caso de la curación de un linfoma de Hodgkin

por el SARS-CoV-2

Se acaba de publicar (2/01/2021) en el British Journal of Haemathology el siguiente caso clínico. Varón de 61 años con inflamación de los ganglios y pérdida de peso, recibía hemodiálisis por insuficiencia renal terminal después de un trasplante renal fallido. Se le diagnostica un linfoma de Hodgkin clásico en estadio III (el linfoma afecta a áreas ganglionares localizadas a ambos lados del diafragma o por encima del diafragma y en el bazo). Poco después del diagnóstico, ingresó con dificultad para respirar y se le diagnosticó neumonía por SARS-CoV-2 positivo por PCR. Después de once días, fue dado de alta para convalecer en su casa. No se administró corticosteroides ni inmunoquimioterapia. Cuatro meses después, la inflamación de los ganglios se había reducido y una exploración PET reveló una remisión generalizada del linfoma.
Según los autores, la hipótesis es que la infección por SARS-CoV-2 desencadenó una respuesta inmunitaria antitumoral: las citocinas inflamatorias producidas en respuesta a la infección podrían haber activando células T específicas con antígenos tumorales y células asesinas naturales contra el tumor. El SARS-CoV-2 le había curado el linfoma.

¿Magía potagía? Por lo visto antes ya se había descrito algún caso similar en otro tipo de linfomas que habían remitido espontáneamente antes de tratamiento debido al efecto antitumoral de una neumonía infecciosa y de una colitis por Clostridium difficile.
MicroBio

viernes, 1 de enero de 2021

martes, 29 de diciembre de 2020

Erroll Garner

 

Amazonian rock art newly discovered by researchers provides further proof the rainforest’s earliest inhabitants lived alongside now-extinct giant Ice Age animals.








Amazonian rock art newly discovered by researchers provides further proof the rainforest’s earliest inhabitants lived alongside now-extinct giant Ice Age animals.

The thousands of pictures are among the oldest depictions of people interacting with the huge creatures, including mastodons. Usually the only clues about their appearance are skeletal remains.

This is one of the largest collections of rock art found in South America. The recorded drawings,likely first made around 12,600 and 11,800 years ago, are on three rock shelters on hills in the Colombian Amazon. The paintings, identified during landscape surveys, also depict geometric shapes, human figures, and handprints, as well as hunting scenes and people interacting with plants, trees and savannah animals. The vibrant red pictures were produced over a period of hundreds, or possibly thousands, of years. Some are so high, and inaccessible, special ladders crafted from forest resources would have been needed and they would have been obscured from view for anyone visiting the rock shelter.

There are drawings of deer, tapirs, alligators, bats, monkeys, turtles, serpents, and porcupines, as well as what appears to be Ice Age megafauna. These now extinct animals are depicted in rock art in Central Brazil, but experts believe these drawings are more realistic. There are depictions of creatures resembling a giant sloth, mastodon, camelids, horses, and three-toe ungulates with trunks. These native animals all became extinct, probably because of a combination of climate change, the loss of their habitat and hunting by humans.

The excavations, in the deep soil around the shelters, have revealed one of the earliest secure dates for the occupation of the Columbian Amazon and clues about people’s diet at this time, as well as the remains of small tools and scraped ochre used to extract pigments to make the paintings.

Communities who lived in the area at the time the drawings were made were hunter-gatherers who fished in the nearby river. Bones and plant remains found during the excavations show they ate palm and tree fruits, piranha, alligators, snakes, frogs, rodents such as paca and capybara, and armadillos.

The discovery was made by researchers on the ERC project LASTJOURNEY, who are working to discover when people settled in Amazonia, and the impact their farming and hunting had on the biodiversity of the region. It features in a new Channel 4 series, Jungle Mystery: Lost Kingdoms of the Amazon. The findings are also outlined in an article in the journal Quaternary International.

The paintings, on specially prepared rock walls of the Serranía La Lindosa, on the northern edge of the Colombian Amazon, is further evidence of the impact early human communities had on the Amazon’s biodiversity and their adaption to climate change. At the time the drawings were made temperatures were rising, starting the transformation of the area from a mosaic landscape of patchy savannahs, thorny scrub, gallery forests and tropical forest with montane elements into the broadleaf tropical Amazon forest of today.

The rock shelters are far from modern settlements and trails, but were known to some local communities, who helped researchers explore them.

The research has been made possible following the 2016 peace treaty between te FARC and the Colombian Government.

The research was carried out by Gaspar Morcote-Ríos, from the Universidad Nacional de Colombia, Francisco Javier Aceituno, from the Universidad de Antioquia, José Iriarte and Mark Robinson from the University of Exeter and Jeison L. Chaparro-Cárdenas from the Universidad Nacional de Colombia.

Dr Robinson said: “These really are incredible images, produced by the earliest people to live in western Amazonia. They moved into the region at a time of extreme climate change, which was leading to changes in vegetation and the make-up of the forest. The Amazon was still transforming into the tropical forest we recognise today.

“The paintings give a vivid and exciting glimpse in to the lives of these communities. It is unbelievable to us today to think they lived among, and hunted, giant herbivores, some which were the size of a small car.”

The rock shelters are exposed to the elements, meaning other paintings in the Amazon discovered by experts have been damaged and the pictures are unclear. Communities exfoliated, or peeled, the rock using fire to create smooth surfaces for their art.

These new discoveries are in shelters more protected through overhanging rock, or the wind and rain blowing in a different direction.

Professor Iriarte said: “These rock paintings are spectacular evidence of how humans reconstructed the land, and how they hunted, farmed and fished. It is likely art was a powerful part of culture and a way for people to connect socially. The pictures show how people would have lived amongst giant, now extinct, animals, which they hunted.”

Experts carried out the excavations in 2017 and 2018. The largest set of paintings was found at Cerro Azul, where there is a total of 12 panels and thousands of individual pictographs depicting humans, animals, plants, handprints and geometric shapes. Paintings at Cerro Montoya and Limoncillos were more faded.

The discovery features in new series on the Amazon, coming to Channel 4 in first week in December - Jungle Mystery: Lost Kingdoms of The Amazon. Fronted by Ella Al Shamahi, the series explores lost civilisations and uncovers never seen before hidden ancient settlements and rock art.

Date: 30 November 2020

martes, 15 de diciembre de 2020

domingo, 6 de diciembre de 2020

Sigo fumando a escondidas (Título original: À mon âge je me cache encore pour fumer )

 Sigo fumando a escondidas

Fátima es una mujer de carácter fuerte que trabaja en un hammam de Argel. Es 1995 y la situación en la capital es tensa, ya que se están aprobando leyes que limitan las libertades de las mujeres. Sin embargo, el hammam es un lugar seguro para encender un cigarrillo o para hablar, lejos de la mirada de los hombres.

sábado, 31 de octubre de 2020